Effect of deuteration of imipramine on its pharmacokinetic properties in the rat.

@article{Taylor1983EffectOD,
  title={Effect of deuteration of imipramine on its pharmacokinetic properties in the rat.},
  author={I W Taylor and Costas Ioannides and Paul J. Sacra and Joseph C. Turner and Dennis V. Parke},
  journal={Biochemical pharmacology},
  year={1983},
  volume={32 4},
  pages={641-7}
}
Imipramine was specifically deuterated in either both aromatic rings or in the N-methyl group, or in both positions, and the pharmacokinetic properties of the products were determined in the rat and compared with those of the non-deuterated analogue. Deuteration of imipramine resulted in a small but significant isotope effect on N-demethylation while… CONTINUE READING