Effect of desmethyldiazepam and chlordesmethyldiazepam on 3′,5′-cyclic guanosine monophosphate levels in rat cerebellum

@article{Govoni2004EffectOD,
  title={Effect of desmethyldiazepam and chlordesmethyldiazepam on 3′,5′-cyclic guanosine monophosphate levels in rat cerebellum},
  author={Stefano Govoni and Paola Fresia and PierFranco Spano and Marco Trabucchi},
  journal={Psychopharmacology},
  year={2004},
  volume={50},
  pages={241-244}
}
Three different benzodiazepines (diazepam, its pharmacologically active metabolite desmethyldiazepam, and the derivative chlordesmethyldiazepam) have been compared in our study for their effects on 3′,5′-guanosine monophosphate (cGMP) cerebellar levels. Desmethyldiazepam and chlordesmethyldiazepam are several-fold more potent that diazepam in decreasing rat cyclic cGMP cerebellar concentrations. None of the three drugs induces detectable changes of cerebellar cyclic 3′,5′-adenosine… 

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