Effect of deslorelin dose in the treatment of central precocious puberty.

@article{Pescovitz1991EffectOD,
  title={Effect of deslorelin dose in the treatment of central precocious puberty.},
  author={Ora Hirsch Pescovitz and Kevin M. Barnes and Gordon B. Cutler},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1991},
  volume={72 1},
  pages={60-4}
}
Central precocious puberty is effectively treated with long-acting LHRH analogs (LHRHas). Although at least six LHRHas have now been used in children, there have been no studies to determine the least effective dose of any of these analogs. We sought to determine the effect of decreasing an efficacious dose of deslorelin (D-Trp6-Pro9-NEt-LHRH) on basal and LHRH-stimulated gonadotropins, estradiol levels, and the rates of linear growth and skeletal maturation in subjects with central precocious… CONTINUE READING