Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial.

@article{Shankaran2014EffectOD,
  title={Effect of depth and duration of cooling on deaths in the NICU among neonates with hypoxic ischemic encephalopathy: a randomized clinical trial.},
  author={Seetha Shankaran and Abbot R. Laptook and Athina Pappas and Scott A McDonald and Abhik Das and Jon E. Tyson and Brenda B. Poindexter and Kurt R. Schibler and Edward Bell and Roy Heyne and Claudia Pedroza and Rebecca Bara and Krisa Page Van Meurs and Cathy Grisby and Carolyn M Petrie Huitema and Meena Garg and Richard A. Ehrenkranz and Edward G. Shepherd and Lina F. Chalak and Shannon Elise Goldsmith Hamrick and Amir Muhammad Khan and Anne Marie Reynolds and Matthew Laughon and William E. Truog and Kevin C. Dysart and Waldemar A. Carlo and Michele C. Walsh and Kristi L. Watterberg and Rosemary D. Higgins},
  journal={JAMA},
  year={2014},
  volume={312 24},
  pages={
          2629-39
        }
}
IMPORTANCE Hypothermia at 33.5°C for 72 hours for neonatal hypoxic ischemic encephalopathy reduces death or disability to 44% to 55%; longer cooling and deeper cooling are neuroprotective in animal models. OBJECTIVE To determine if longer duration cooling (120 hours), deeper cooling (32.0°C), or both are superior to cooling at 33.5°C for 72 hours in neonates who are full-term with moderate or severe hypoxic ischemic encephalopathy. DESIGN, SETTING, AND PARTICIPANTS A randomized, 2 × 2… CONTINUE READING

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