Effect of depolymerized holothurian glycosaminoglycan (DHG) on tissue factor pathway inhibitor: in vitro and in vivo studies.

@article{Nagase1997EffectOD,
  title={Effect of depolymerized holothurian glycosaminoglycan (DHG) on tissue factor pathway inhibitor: in vitro and in vivo studies.},
  author={Hideki Nagase and Kei-ichi Enjyoji and Yuichi Kamikubo and Keiko T. Kitazato and Hidehiko Saito and Hisato Kato},
  journal={Thrombosis and haemostasis},
  year={1997},
  volume={78 2},
  pages={864-70}
}
Depolymerized holothurian glycosaminoglycan (DHG) is a glycosaminoglycan extracted from the sea cucumber Stichopus japonicus Selenka. In previous studies, we demonstrated that DHG has antithrombotic and anticoagulant activities that are distinguishable from those of heparin and dermatan sulfate. In the present study, we examined the effect of DHG on the tissue factor pathway inhibitor (TFPI), which inhibits the initial reaction of the tissue factor (TF)-mediated coagulation pathway. We first… CONTINUE READING

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