Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: application in the production of chimeric thymus rudiments.

@article{Jenkinson1982EffectOD,
  title={Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: application in the production of chimeric thymus rudiments.},
  author={Eric J. Jenkinson and Leslie L. Franchi and Rosetta Kingston and J. J. Owen},
  journal={European journal of immunology},
  year={1982},
  volume={12 7},
  pages={583-7}
}
On the basis of reports that deoxyguanosine is selectively toxic for adult T lymphocytes, the usefulness of this compound in the production of lymphocyte-depleted embryonic thymus rudiments in an in vitro organ culture system was investigated. The results showed that a period of exposure to deoxyguanosine causes depletion of the lymphoid cells while the stromal elements continue to survive, with many of the cells showing an epithelial morphology and expression of I region products of the major… CONTINUE READING

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