Effect of deletion of gene cluster involved in synthesis of Enterobacterial common antigen on virulence and immunogenicity of live attenuated Salmonella vaccine when delivering heterologous Streptococcus pneumoniae antigen PspA

@article{Liu2020EffectOD,
  title={Effect of deletion of gene cluster involved in synthesis of Enterobacterial common antigen on virulence and immunogenicity of live attenuated Salmonella vaccine when delivering heterologous Streptococcus pneumoniae antigen PspA},
  author={Q. Liu and Xuegang Shen and Xiaoping Bian and Q. Kong},
  journal={BMC Microbiology},
  year={2020},
  volume={20}
}
  • Q. Liu, Xuegang Shen, +1 author Q. Kong
  • Published 2020
  • Biology, Medicine
  • BMC Microbiology
  • Enterobacterial common antigen (ECA) is a family-specific surface antigen shared by all members of the Enterobacteriaceae family. Previous studies showed that the loss of ECA results in Salmonella attenuation, indicating its usefulness as a vaccine candidate for Salmonella infection, but no studies have shown whether the mutation resulting from the deletion of the ECA operon in conjunction with other mutations could be used as an antigen vehicle for heterologous protein antigen delivery. In… CONTINUE READING

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