Effect of delayed cerebral vasospasm on cerebrovascular endothelin A receptor expression and function.

@article{Vatter2007EffectOD,
  title={Effect of delayed cerebral vasospasm on cerebrovascular endothelin A receptor expression and function.},
  author={Hartmut Vatter and Juergen Konczalla and Stefan Weidauer and Christine Preibisch and Michael Zimmermann and Andreas Raabe and V. Seifert},
  journal={Journal of neurosurgery},
  year={2007},
  volume={107 1},
  pages={121-7}
}
OBJECT The key role in the development of cerebral vasospasm after subarachnoid hemorrhage (SAH) is increasingly assigned to endothelin (ET)-1. Constriction of the cerebrovasculature by ET-1 is mainly mediated by the ET(A) receptor but is putatively altered during the development of cerebral vasospasm. Therefore, the aim in the present study was to characterize these alterations, with the emphasis on the ET(A) receptor. METHODS Cerebral vasospasm was induced using the rat double-hemorrhage… CONTINUE READING

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