Effect of dehydroepiandrosterone on atherosclerosis in apolipoprotein E-deficient mice.

@article{Yamakawa2009EffectOD,
  title={Effect of dehydroepiandrosterone on atherosclerosis in apolipoprotein E-deficient mice.},
  author={T. Yamakawa and K. Ogihara and M. Nakamura and H. Utsunomiya and K. Kadonosono and S. Kishikawa and Y. Terauchi},
  journal={Journal of atherosclerosis and thrombosis},
  year={2009},
  volume={16 4},
  pages={
          501-8
        }
}
AIM Several clinical trials have indicated that dehydroepiandrosterone (DHEA) reduces coronary events associated with atherosclerosis. The aim of this study was to examine the inhibitory effect of DHEA on atherosclerosis and the mechanisms involved. METHODS Apolipoprotein E-knockout (apoE-KO) mice were fed an atherogenic high-cholesterol diet with or without 0.4% (w/w) DHEA for 12 weeks. RESULTS Although the plasma cholesterol and triglyceride levels were not decreased by DHEA… Expand
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