Effect of defensin peptides on eukaryotic cells: primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines.

@article{Nishimura2004EffectOD,
  title={Effect of defensin peptides on eukaryotic cells: primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines.},
  author={Michiko Nishimura and Yoshihiro Abiko and Yoshihito Kurashige and Maiko Takeshima and Mami Yamazaki and Kaoru Kusano and Masato Saitoh and K Nakashima and Takashi Inoue and Tohru Kaku},
  journal={Journal of dermatological science},
  year={2004},
  volume={36 2},
  pages={87-95}
}
BACKGROUND Although the usefulness of the antimicrobial peptides known as defensins has been suggested against oral and skin infections, possible adverse effects of the defensins on the host should be understood before clinical applications can be contemplated. OBJECTIVE In the present study, we investigated how alpha-defensin (HNP-1) and beta-defensins (hBD-1, -2, -3) affect cells including primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines, SCC-9 and KB. METHOD… CONTINUE READING