Effect of decreased dopamine synthesis on the development of hypertension induced by salt loading in spontaneously hypertensive rats.

@article{Yoshimura1987EffectOD,
  title={Effect of decreased dopamine synthesis on the development of hypertension induced by salt loading in spontaneously hypertensive rats.},
  author={Manabu Yoshimura and Seiichi Kambara and Hideoki Okabayashi and H. Takahashi and Hamao Ijichi},
  journal={Clinical and experimental hypertension. Part A, Theory and practice},
  year={1987},
  volume={9 7},
  pages={
          1141-57
        }
}
To clarify role of dopamine in the development of hypertension, the effect of a dopamine synthesis inhibitor on blood pressure and urinary output of catecholamines was investigated in spontaneously hypertensive rats (SHR) fed with high sodium diet. Rats were orally given carbidopa, an inhibitor of peripheral DOPA decarboxylase, or the vehicle for 4 weeks. Carbidopa administration accelerated significantly the development of hypertension as compared to the control SHRs with the vehicle… 

INVOLVEMENT OF DOPAMINE IN DEVELOPMENT OF HYPERTENSION INHIBITOR OF PERIPHERAL DOPA DECARBOXYLASE IN SPONTANEOUSLY HYPERTENSIVE RAT: EFFECT OF CARBIDOPA,

The demonstration of acceleration of hypertension was investigated in spontaneously hypertensive rats (SHR) treated with carbidopa, inhibitor of peripheral dopa decarboxylase, and positive correlation between systolic blood pressure and renal content of NE were significantly observed.

Involvement of dopamine in development of hypertension in spontaneously hypertensive rat: effect of carbidopa, inhibitor of peripheral dopa decarboxylase.

The results suggest that decreased DA biosynthesis in peripheral tissues accelerates development of hypertension mediated by decrease of natriuresis and enhanced release of NE in the kidneys of SHR.

Contributions Attenuated Renal Response to Dopaminergic Drugs in Spontaneously Hypertensive Rats

The hypothesis that the abnormal sodium handling in spontaneously hypertensive rats (Okamoto-Aoki strain) is related to a decreased dopaminergic response is tested by studying the effects of the intrarenal infusion of the dopamine-1 agonist SKF-38393 and the dopamine -1 antagonist SCH-23390 in hypertensive and in normotensive Wistar-Kyoto rats.

Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats.

The hypothesis that the abnormal sodium handling in spontaneously hypertensive rats (Okamoto-Aoki strain) is related to a decreased dopaminergic response is tested by studying the effects of the intrarenal infusion of the dopamine-1 agonist SKF-38393 and the dopamine -1 antagonist SCH-23390 in hypertensive and in normotensive Wistar-Kyoto rats.

Involvement of renal dopaminergic system in experimental neurogenic arterial hypertension.

Data show an alteration of the renal dopamine system in hypertensive sinoaortic denervated dogs suggesting that a dopaminergic impairment can appear during the development of arterial neurogenic hypertension.

Comparative hypertensionology-renal dopaminergic activity in experimental hypertensive rats.

Estimation of the pathogenetic and pathophysiological role of renal dopamine in connection with renal kallikrein-kinin and prostaglandin systems in various experimental hypertensive models concluded that decreased renal dopamine production is important in the pathogenesis of human essential hypertension.

COMPARATIVE HYPERTENSIONOLOGY HYPERTENSIVE RATS -RENAL DOPAMINERGIC ACTIVITY IN EXPERIMENTAL

Estimation of the pathogenetic and pathophysiological role of renal dopamine in connection with renal kallikreinkinin and prostaglandin systems in various experimental hypertensive models concluded that decreased dopamine production is important in the pathogenesis of human essential hypertension.

Role of dopaminergic mechanisms in the kidney for the pathogenesis of hypertension.

Demonstration of impaired dopaminergic mechanisms in kidneys of human and animal hypertension suggests that renal dopamine synthesis was enhanced whereas there was a decrease of adenylate cyclase activity in renal tubules.

RENAL DOPAMINERGIC MECHANISMS AND HYPERTENSION: A CHRONOLOGY OF ADVANCES

Aberrant renal dopamine production and/or dopamine receptor function have been reported in salt-dependent and low-renin forms of human primary hypertension as well as in genetic models of animal hypertension, including the SHR and Dahl SS rat.

Young SHR express increased type 1 angiotensin II receptors in renal proximal tubule.

Young, but not adult, SHR have increased expression of proximal tubule AT1R and that chronic L-DOPA or captopril treatment decreased the elevated At1R expression to control levels, providing further support for an important role of the RAS in the development of hypertension in SHR.

References

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