Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans.

@article{Manabe2010EffectOD,
  title={Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans.},
  author={Noriaki Manabe and Michael Joseph Camilleri and Archana S. Rao and Banny S. Wong and Duane Burton and Irene A Busciglio and Alan R. Zinsmeister and Ken Haruma},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2010},
  volume={298 6},
  pages={
          G970-5
        }
}
Daikenchuto (TU-100) is a traditional Japanese (Kampo) medicine used to treat postoperative ileus. TU-100 dose dependently increases gastrointestinal (GI) motility by modulating cholinergic and serotonergic mechanisms in animal studies. The aim of this study was to evaluate the effects of orally administered TU-100 on GI and colonic transit and bowel function in healthy humans. In a randomized, parallel-group, double-blind, placebo-controlled, dose-response study, 60 healthy subjects were… 
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Citation Type

Effect of Traditional Japanese Medicine, Daikenchuto (TJ-100) in Patients With Chronic Constipation
TLDR
The addition of a traditional Japanese medicine, TJ-100, reduced bloating and abdominal pain in patients with chronic constipation receiving stimulant laxatives, possibly by decreasing the bowel gas volume.
Intestinal, portal, and peripheral profiles of daikenchuto (TU-100)'s active ingredients after oral administration
TLDR
The effect of TU‐100 on the intestines is believed to be a composite of multiple actions by multiple compounds supplied via multiple routes, including pepper, ginger, and ginseng.
Effects of Daikenchuto, a Japanese Herb, on Intestinal Motility After Total Gastrectomy: a Prospective Randomized Trial
TLDR
DKT improved bowel movements, stool properties, and bowel gas, and the results suggested that DKT promoted early postoperative bowel functions after total gastrectomy.
Effects of Daikenchuto on Abdominal Bloating Accompanied by Chronic Constipation: A Prospective, Single-Center Randomized Open Trial
Effect of Daikenchuto, a Traditional Japanese Herbal Medicine, after Total Gastrectomy for Gastric Cancer: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase II Trial.
Intragastric Dai-Kenchu-To, a Japanese herbal medicine, stimulates colonic motility via transient receptor potential cation channel subfamily V member 1 in dogs.
TLDR
Results indicate that orally administered DKT stimulates colonic motility via TRPV1, muscarinic, nicotinic, and 5-hydroxytryptamine-3 receptors, thereby providing scientific support for the efficacy of oral DKT in chronic constipation.
Acceleration of small bowel motility after oral administration of dai-kenchu-to (TJ-100) assessed by cine magnetic resonance imaging
TLDR
Cine MRI demonstrated that TJ-100 activated intestinal motility without dependence on ileum distention, and differences were observed in the bowel distention scores.
Efficacy and Safety of Daikenchuto for Constipation and Dose-Dependent Differences in Clinical Effects
TLDR
It is suggested that DKT increases defaecation frequency and is safe for treating constipation.
The effects of the herbal medicine Daikenchuto (TJ-100) after esophageal cancer resection, open-label, randomized controlled trial
TLDR
TJ-100 treatment after esophageal cancer resection has the effects of prompting the recovery of gastrointestinal motility and minimizing body weight loss, and it might suppress the excess inflammatory reaction related to surgery.
Randomised clinical trial: the effects of daikenchuto, TU‐100, on gastrointestinal and colonic transit, anorectal and bowel function in female patients with functional constipation
Daikenchuto, a Japanese herbal medicine used for post‐operative ileus and constipation, dose dependently stimulates gastrointestinal (GI) motility and decreases rectal compliance and sensation.…
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TLDR
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