Effect of d-limonene, alpha-pinene and cineole on in vitro transdermal human skin penetration of chlorpromazine and haloperidol.

@article{Almirall1996EffectOD,
  title={Effect of d-limonene, alpha-pinene and cineole on in vitro transdermal human skin penetration of chlorpromazine and haloperidol.},
  author={Miriam Almirall and Javier Monta{\~n}a and Elvira Escribano and Rosendo Obach and J D Berrozpe},
  journal={Arzneimittel-Forschung},
  year={1996},
  volume={46 7},
  pages={676-80}
}
The aim of this research is to carry out a comparative study of the ability to cross human skin of two neuroleptic drugs: chlorpromazine (CAS 50-53-3) and haloperidol (CAS 52-86-8), in the absence and in the presence of three terpenes (cineole, d-limonene and alpha-pinene) with the purpose of considering the possibility of improving their transdermal penetration profile. Franz diffusion cells were used, in conjunction with human skin as permeation membrane. The permeation parameters calculated… CONTINUE READING