Effect of cytoplasmic acidification on the membrane potential of T-lymphocytes: Role of trace metals

Abstract

The effect of lowering intracellular pH on the membrane potential (E m ) of rat thymic lymphocytes was studied using the potential-sensitive dyebis-oxonol. Cells were acid loaded by addition of the electroneutral K+/H+ exchanging ionophore nigericin. Acidification to pH 6.3 in Na+-free solution resulted in a biphasic change inE m : an early transient… (More)
DOI: 10.1007/BF01868672

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