Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome.

@article{Frere2008EffectOC,
  title={Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome.},
  author={Corinne Frere and Thomas Cuisset and Pierre-Emmanuel Morange and Jacques Quilici and Laurence Camoin-Jau and No{\'e}mie Saut and Doroth{\'e}e Faille and Marc Lambert and Ir{\'e}ne Juhan-Vague and Jean-louis Bonnet and Marie-Christine Alessi},
  journal={The American journal of cardiology},
  year={2008},
  volume={101 8},
  pages={
          1088-93
        }
}
Genetic polymorphisms of cytochrome P450 (CYP) isoforms may promote variability in platelet response to clopidogrel. This study was conducted to analyze, in 603 patients with non-ST elevation acute coronary syndromes, the effect of CYP3A4, CYP3A5, and CYP2C19 gene polymorphisms on clopidogrel response and post-treatment platelet reactivity assessed by adenosine diphosphate (ADP)-induced platelet aggregation, vasodilator-stimulated phosphoprotein phosphorylation index, and ADP-induced P-selectin… CONTINUE READING

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