Effect of cytochalasin B and colchicine on the stimulation of -amylase release from rat parotid tissue slices.

@article{Butcher1972EffectOC,
  title={Effect of cytochalasin B and colchicine on the stimulation of -amylase release from rat parotid tissue slices.},
  author={Fred R. Butcher and Rose Hannah Goldman},
  journal={Biochemical and biophysical research communications},
  year={1972},
  volume={48 1},
  pages={
          23-9
        }
}
  • Fred R. Butcher, Rose Hannah Goldman
  • Published 1972
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • A role for microfilaments and microtubules in the secretion of α-amylase is indicated since cytochalasin B and colchicine inhibited the stimulation of α-amylase release by epinephrine (30 or 15 μM) but only cytochalasin B inhibited the stimulation by N6, O2′ dibutyryl adenosine 3′,5′monophosphate (1.0 mM). It was necessary to incubate the parotid tissue slices in the presence of cytochalasin B (1 hr.) or colchicine (4 hrs.) before adding the agonist in order to see the inhibitory effects. 

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