Effect of cytoarchitecture on the transport and localization of protein synthetic machinery

@article{LubyPhelps1993EffectOC,
  title={Effect of cytoarchitecture on the transport and localization of protein synthetic machinery},
  author={K. Luby-Phelps},
  journal={Journal of Cellular Biochemistry},
  year={1993},
  volume={52}
}
  • K. Luby-Phelps
  • Published 1993
  • Biology, Medicine
  • Journal of Cellular Biochemistry
The emerging picture of cytoarchitecture imposes constraints on the transport and localization of several components of the protein synthetic machinery. The range in which “free” polysomes can diffuse through the cytoplasm may be restricted to about 50 nm due to obstruction by cytoskeletal barriers. Individual ribosomes and large transcripts will diffuse at least 4–10 times slower in cytoplasm than in dilute aqueous solution and may be sterically excluded from some cytoplasmic domains. The… Expand
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