Effect of cyclosporine withdrawal on mycophenolic acid pharmacokinetics in kidney transplant recipients with deteriorating renal function: preliminary report.

@article{Shipkova2001EffectOC,
  title={Effect of cyclosporine withdrawal on mycophenolic acid pharmacokinetics in kidney transplant recipients with deteriorating renal function: preliminary report.},
  author={Maria Shipkova and Victor William Armstrong and Dirk Kuypers and Ferenc Perner and V Fabrizi and Herwig Holzer and Eberhard Wieland and Michael Oellerich},
  journal={Therapeutic drug monitoring},
  year={2001},
  volume={23 6},
  pages={717-21}
}
Mycophenolic acid (MPA) concentrations are lower in transplant recipients receiving mycophenolate mofetil (MMF) and cyclosporine compared with MMF with tacrolimus. It is not clear whether this is due to an effect of cyclosporin or tacrolimus on MPA pharmacokinetics. To study this effect, kidney transplant recipients with deteriorating renal function (n = 5) receiving cyclosporin and steroids were given mycophenolate mofetil over 4 weeks during a run-in phase (1 g/d in week 1, 1.5 g/d in week 2… CONTINUE READING

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