Effect of cyclosporine on the diluting capacity of the rat kidney.

@article{Gnutzmann1986EffectOC,
  title={Effect of cyclosporine on the diluting capacity of the rat kidney.},
  author={K H Gnutzmann and Klaus Hering and Hans Ulrich Gutsche},
  journal={Clinical nephrology},
  year={1986},
  volume={25 Suppl 1},
  pages={S51-6}
}
Micropuncture experiments were carried out on rat kidneys in order to analyze the diluting ability of the thick ascending limb of Henle's loop (TAL) after acute and chronic administration of cyclosporine. Male albino Wistar rats weighing 190 to 250 g were either given cyclosporine (CSA) orally for 10 days or received single i.v. infusions of the drug before the micropuncture experiments. Drug free vehicle was administered to animals of two respective control groups. The electrolyte… CONTINUE READING

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