Effect of cyclophosphamide on serum ceruloplasmin oxidase activity in sarcoma bearing rats.


High levels of serum ceruloplasmin oxidase activity were detected in U strain isogenic male rats bearing a syngeneic sarcoma in all phases of tumoral evolution. Normal levels of ceruloplasmin were only observed after a single i.p. dose of cyclophosphamide (100 mg/kg). However subsequent weekly administration of the drug did not prevent the return of… (More)


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