Effect of cyclooxygenase-2 inhibition on renal function in elderly persons receiving a low-salt diet. A randomized, controlled trial.

@article{Swan2000EffectOC,
  title={Effect of cyclooxygenase-2 inhibition on renal function in elderly persons receiving a low-salt diet. A randomized, controlled trial.},
  author={Suzanne K. Swan and David W. Rudy and Kenneth C. Lasseter and C. Frank Ryan and Kerstin B{\"u}chel and Lawrence J Lambrecht and Mary Beth Pinto and Stacy C. Dilzer and O Obrda and Krister Sundblad and Carol P Gumbs and David L. Ebel and Hui Quan and Patrick J Larson and Jules I. Schwartz and Thomas A Musliner and Barry J. Gertz and Dr D. Craig Brater and Shimou Yao},
  journal={Annals of internal medicine},
  year={2000},
  volume={133 1},
  pages={1-9}
}
BACKGROUND Most nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both cyclooxygenase-1 (COX-1), whose inhibition is associated with gastrointestinal ulceration, and COX-2, whose inhibition is associated with therapeutic benefits. Although agents that do not produce COX-1 activity may have fewer adverse effects, targeted disruption of the COX-2 allele in mice has resulted in severe renal problems, suggesting that COX-2 inhibition may also produce adverse effects. OBJECTIVE To determine… CONTINUE READING

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