Effect of cyclodextrin infusion in a rat model of verapamil toxicity.

Abstract

Sulfobutylether-β-cyclodextrin (SBE-CD) is a pharmaceutical excipient known to bind verapamil. After intravenous administration, clearance of SBE-CD approximates glomerular filtration rate. We hypothesized that SBE-CD would complex with verapamil in vivo, enhance renal elimination, and increase time to death in a rat model of verapamil toxicity. Ten Wistar… (More)
DOI: 10.1097/MJT.0b013e3181ea3173

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