• Corpus ID: 29493091

Effect of cyclic nucleotide phosphodiesterase regulators on isolated rat uterus: with observations on their mechanism of action.

@article{Singh1985EffectOC,
  title={Effect of cyclic nucleotide phosphodiesterase regulators on isolated rat uterus: with observations on their mechanism of action.},
  author={M. Singh and P. L. Sharma},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1985},
  volume={273 2},
  pages={
          180-95
        }
}
  • M. Singh, P. Sharma
  • Published 1 February 1985
  • Biology, Chemistry
  • Archives internationales de pharmacodynamie et de therapie
The effect of PDE regulators on isolated rat uterus and their probable mechanism of action was investigated. The potassium chloride-induced contracture was enhanced by imidazole (3.67 X 10(-3)M) and potassium bicarbonate (1.5 X 10(-2)M). In contrast, imidazole (pH adjusted with potassium dihydrogen orthophosphate or HCl) produced a biphasic effect, i.e. initial transient relaxation followed by a sustained contracture. A similar biphasic effect of imidazole was observed in uterine preparations… 
The inhibitory effects of amrinone on isolated rat uterus
  • Y. KesimS. CelikN. Banoglu
  • Biology, Chemistry
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
  • 1994
TLDR
It was concluded that amrinone could behave as a calcium antagonist and PDE inhibitor.
Imidazole-induced contractions in bovine tracheal smooth muscle are not dependent on the cAMP pathway
TLDR
CAMP did not appear to play a role in imidazole-induced contraction, suggesting other mechanisms, such as the release of endogenous acetylcholine, which was greater in bovine trachea compared to the other species tested.