Effect of curcumin in prevention of pre-invasive lesions of the cervix

@article{Rashi2017EffectOC,
  title={Effect of curcumin in prevention of pre-invasive lesions of the cervix},
  author={Rashi and Shaheen and Rajyashri Sharma and Bandawane Deepti},
  journal={International journal of reproduction, contraception, obstetrics and gynecology},
  year={2017},
  volume={6},
  pages={1461-1466}
}
  • Rashi, Shaheen, +1 author B. Deepti
  • Published 30 March 2017
  • Medicine
  • International journal of reproduction, contraception, obstetrics and gynecology
Background: Cervical cancer is the leading cause of deaths of women due to malignancies in developing countries world-wide. Having a latency period of upto10 years, pre-invasive lesions of cervix give us a wide margin for detection and treatment before it becomes cancerous. It has been estimated that even after putting in all the resources it’s not possible to screen one fourth of the population of women in India. This is the aim of this study to establish a pattern of prevalence of these pre… Expand
Effect of curcumin in prevention of pre-invasive lesions of the cervix
TLDR
Cervical cancer being one of the most easily preventable cancer owing to the easy accessibility of the cervix to the clinician, and easy screening methods available, is amenable to eradication of the disease one day. Expand

References

SHOWING 1-10 OF 24 REFERENCES
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
TLDR
It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested. Expand
Cervical cancer screening: Current knowledge & practice among women in a rural population of Kerala, India
TLDR
Specific knowledge on cervical cancer screening is a critical element in determining whether a woman will undergo Pap test in addition to making cancer screening facilities available in the primary health centre. Expand
NATURAL HISTORY OF CERVICAL SQUAMOUS INTRAEPITHELIAL LESIONS: A META‐ANALYSIS
TLDR
The findings for borderline and low-grade abnormal cervical cytologic results suggest a relatively low risk of invasive cervical cancer with observation up to 24 months and support the clinical policy of early colposcopy for high-grade lesions. Expand
Epidemiological evidence for age-dependent regression of pre-invasive cervical cancer.
TLDR
The findings about progression and duration of pre-invasive lesions do not support the still prevailing tendency of frequently making Pap smears in young women. Expand
Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications.
TLDR
Curcumin's potent anti-proliferative activity interacting with several intracellular signal transduction pathways may potentiate the anti-tumor effect of gemcitabine. Expand
Prevalence of high--risk human papillomavirus infections in women with benign cervical cytology: a hospital based study from North India.
TLDR
The study generates epidemiological data of prevalence of sub-clinical HPV in the women visiting a tertiary care institute as well as peripheral health centres, which will be useful for laying guidelines for mass screening of HPV, treatment and prophylaxis in the local population. Expand
Accuracy of the Papanicolaou Test in Screening for and Follow-up of Cervical Cytologic Abnormalities
TLDR
A primary objective was to systematically review the characteristics of conventional and new methods of Pap testing, including neural network computerized imaging of Papanicolaou smear slides, and one that uses neural networks. Expand
Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP‐1 translocation, and modulation of apoptosis
TLDR
Findings indicate curcumin to be cytotoxic to cervical cancer cells in a concentration‐dependent and time‐dependent manner and provides attractive data for the possible use ofCurcumin in the management of HPV associated tumors. Expand
New Perspectives of Curcumin in Cancer Prevention
TLDR
The potential of curcumin in cancer prevention, its molecular targets, and mechanisms of action, and specific recommendations to improve its efficacy and bioavailability for clinical applications are reviewed. Expand
Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16 573 women with cervical cancer and 35 509 women without cervical cancer from 24 epidemiological studies
TLDR
The relative risk of cervical cancer is increased in current users of oral contraceptives and declines after use ceases, and by 10 or more years had returned to that of never users. Expand
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