Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages

@article{Joe1997EffectOC,
  title={Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages},
  author={Bina Joe and Belur Ramaswamy Lokesh},
  journal={Lipids},
  year={1997},
  volume={32},
  pages={1173-1180}
}
The inflammatory mediators secreted by macrophages play an important role in autoimmune diseases. Spice components, such as curcumin from turmeric and capsaicin from red pepper, are shown to exhibit antiinflammatory properties. The influence of these spice components on arachidonic acid metabolism and secretion of lysosomal enzymes by macrophages was investigated. Rat peritoneal macrophages preincubated with 10 μM curcumin or capsaicin for 1 h inhibited the incorporation of arachidonic acid… 

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