Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages

  title={Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages},
  author={Bina Joe and Belur Ramaswamy Lokesh},
The inflammatory mediators secreted by macrophages play an important role in autoimmune diseases. Spice components, such as curcumin from turmeric and capsaicin from red pepper, are shown to exhibit antiinflammatory properties. The influence of these spice components on arachidonic acid metabolism and secretion of lysosomal enzymes by macrophages was investigated. Rat peritoneal macrophages preincubated with 10 μM curcumin or capsaicin for 1 h inhibited the incorporation of arachidonic acid… 

Mass-Spectrometric Identification of T-Kininogen I/Thiostatin as an Acute-Phase Inflammatory Protein Suppressed by Curcumin and Capsaicin

The results demonstrate that curcumin and capsaicin lower the acute-phase inflammatory response, the molecular mechanism for which is, in part, mediated by pathways associated with the lowering of T-kininogen I.


This study demonstrates the significant anti-inflammatory property of combined curcumin and capsaicin at half of the individual concentration of curCumin and Capsaicin.

Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin 1β-treated articular cartilage

Curcumin is a phytochemical with potent anti-inflammatory and anti-oxidant properties, and has therapeutic potential for the treatment of a range of inflammatory diseases, including osteoarthritis.

The effect of turmeric extracts on inflammatory mediator production.

Spice phenolics inhibit human PMNL 5-lipoxygenase.

Dietary n-3 fatty acids, curcumin and capsaicin lower the release of lysosomal enzymes and eicosanoids in rat peritoneal macrophages

These studies indicated that dietary cod-liver oil (rich in n-3 fatty acids), and spice principles curcumin and capsaicin can lower the secretory functions of macrophages in a beneficial manner.

Regulation of COX and LOX by curcumin.

  • C. Rao
  • Biology
    Advances in experimental medicine and biology
  • 2007
Evidence that supports the regulation of COX and LOX enzymes by curcumin as the key mechanism for its beneficial effects in preventing various inflammatory diseases is discussed.

Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase‐2 induction by capsaicin and related analogs in macrophages

Vanilloids can modulate the expression of inflammatory iNOS and COX‐2 genes in macrophages through interference with upstream signalling events of LPS and IFN‐γ.



Intracellular calcium does not appear to be essential for arachidonic acid release from stimulated macrophages as shown by studies with Quin-2.

Effect of curcumin on certain lysosomal hydrolases in isoproterenol-induced myocardial infarction in rats.

Rats treated with isoproterenol showed a significant increase in serum lysosomal hydrolase activities, which were found to decrease after curcumin treatment, and Histopathological studies of the infarcted rat heart showed a decreased degree of necrosis after cur cumin treatment.

Studies on anti-inflammatory activity of spice principles and dietary n-3 polyunsaturated fatty acids on carrageenan-induced inflammation in rats.

Combinations of dietary lipids with spice principles like eugenol can help in lowering inflammation.

Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

Production of PGE2 and collagenase in large amounts in vitro by cells dispersed with proteolytic enzymes from rheumatoid arthritic synovectomy specimens suggests that they may be involved in joint destruction in vivo.

Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes.

Evidence is provided that G-proteins may be involved in either the enhancement or suppression of the eicosanoid-cAMP-dependent signal transduction pathway that results in the production of monocyte MMPs.

Glucan receptor and zymosan-induced lysosomal enzyme secretion in macrophages.

Binding of ligand to the beta-glucan receptor and inhibition of the lysosomal secretory response to zymosan were both more efficient with glucans of larger size, indicating that clustering of glucan receptors at the cell surface occurs.