Effect of coumestrol on bone metabolism in organ culture.

Abstract

Coumestrol, a representative phytoestrogen, inhibited bone resorption-stimulating agent-induced bone resorption, whereas it did not inhibit basal bone resorption of cultured fetal rat limb bone. Coumestrol increased the calcium content of 9-d-old chick embryonic femurs in organ culture, indicating that this phytoestrogen stimulated bone-mineralizing… (More)

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