Effect of coronary stenosis severity on variability of quantitative arteriography, and implications for interventional trials.

Abstract

Q uantitative coronary arteriography is now routinely used in studies assessing arterial remodelling in response to interventions such as lipid lowering and percutaneous transltinal coronary angioplasty. Although this methodology provides both relative and absolute measurements that can be evaluated statistically as continuous variables, it is, however, often desirable or necessary to establish categorical responses to the interventions based on the variability inherent in the quantitative methods (i.e., it is often necessary to state whether individual patients, as opposed to entire groups, have “restenosed,” “progressed, ” “regressed,” and so forth, and these categorical designations are based on critical limits of variability).lv2 These limits are generally based on an analysis of a rather diverse range of lesion severity, and the question arises as to whether the variability of measuring changes in lesion or segment morphology is affected by the initial severity of the lesion being studied. It is con-

Cite this paper

@article{Mancini1992EffectOC, title={Effect of coronary stenosis severity on variability of quantitative arteriography, and implications for interventional trials.}, author={G. B. John Mancini and Paul R. Williamson and S F Deboe}, journal={The American journal of cardiology}, year={1992}, volume={69 8}, pages={806-7} }