Effect of copper(II) chloride on suppression of racemization in peptide synthesis by the mixed anhydride and related methods.

Abstract

In segment couplings by the mixed anhydride method using isobutyloxycarbonyl chloride, the use of copper(II) chloride as an additive suppressed racemization completely in the same manner as in the carbodiimide method reported previously. This was confirmed by employing a number of couplings between Z-dipeptides and amino acid esters. The racemization… (More)

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Cite this paper

@article{Miyazawa1992EffectOC, title={Effect of copper(II) chloride on suppression of racemization in peptide synthesis by the mixed anhydride and related methods.}, author={Teruo Miyazawa and T Donkai and Toshiyuki Yamada and Shoji Kuwata}, journal={International journal of peptide and protein research}, year={1992}, volume={40 1}, pages={49-53} }