Effect of cooperation of chaperones and gene dosage on the expression of porcine PGLYRP-1 in Pichia pastoris

@article{Yang2016EffectOC,
  title={Effect of cooperation of chaperones and gene dosage on the expression of porcine PGLYRP-1 in Pichia pastoris},
  author={Jun Yang and Zhipeng Lu and Jiawei Chen and Pinpin Chu and Qingmei Cheng and Jie Liu and Feiping Ming and Chaoyuan Huang and Anji Xiao and Haiming Cai and Linghua Zhang},
  journal={Applied Microbiology and Biotechnology},
  year={2016},
  volume={100},
  pages={5453-5465}
}
Mammalian peptidoglycan recognition proteins (PGLYRPs) are highly conserved pattern-recognition molecules of the innate immune system with considerable bactericidal activity, which manifest their potential values for the application to food and pharmaceutical industry. However, the effective expression of porcine PGLYRP-1 in Pichia pastoris has not been reported so far. In this study, expression in P. pastoris was explored as an efficient way to produce functional porcine PGLYRP-1. Cooperation… CONTINUE READING
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