Effect of controlled release of platelet-derived growth factor from a porous hydroxyapatite implant on bone ingrowth.

@article{Arm1996EffectOC,
  title={Effect of controlled release of platelet-derived growth factor from a porous hydroxyapatite implant on bone ingrowth.},
  author={Douglas M Arm and Allan F. Tencer and Steven D. Bain and D L Celino},
  journal={Biomaterials},
  year={1996},
  volume={17 7},
  pages={703-9}
}
Platelet-derived growth factor (PDGF) is one of several osteogenic factors which affect bone growth and fracture healing. This study examined the potential of hydroxyapatite (HA) rods with interconnected pores of mean diameter 200 microns to be used as a matrix for the release of PDGF to enhance bone ingrowth into the implant. In the initial phase of the study the sustained release of PDGF from the HA rods was characterized in vitro for two different PDGF loadings, 10 and 100 micrograms per… CONTINUE READING