Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles.

@article{Horcajadas2004EffectOC,
  title={Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles.},
  author={Jos{\'e} Antonio Horcajadas and Anne Riesewijk and Jan Polman and Roselinde van Os and Antonio Pellicer and Sietse Mosselman and Carlos Sim{\'o}n},
  journal={Molecular human reproduction},
  year={2004},
  volume={11 3},
  pages={
          195-205
        }
}
Controlled ovarian hyperstimulation (COH) used in IVF produces lower implantation rates per embryo transferred compared to natural cycles utilized in ovum donation, suggesting a suboptimal endometrial development. Endometrial receptivity has recently been investigated in natural menstrual cycles with the aid of microarray technology. The aim of this study is to investigate the impact of COH using urinary gonadotrophins with a long protocol with GnRH agonists without progesterone supplementation… CONTINUE READING

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Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications.

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