Effect of conjugation methodology, carrier protein, and adjuvants on the immune response to Staphylococcus aureus capsular polysaccharides.

@article{Fattom1995EffectOC,
  title={Effect of conjugation methodology, carrier protein, and adjuvants on the immune response to Staphylococcus aureus capsular polysaccharides.},
  author={Ali I Fattom and Xun Li and Young Ho Cho and Andrew D Burns and Abbas Hawwari and S E Shepherd and Ryan Coughlin and Scott Winston and Robert B Naso},
  journal={Vaccine},
  year={1995},
  volume={13 14},
  pages={1288-93}
}
Conjugate vaccines were prepared with S. aureus type 8 capsular polysaccharide (CP) using three carrier proteins: Pseudomonas aeruginosa exotoxin A (ETA), a non-toxic recombinant ETA (rEPA), and diphtheria toxoid (DTd). Adipic acid dihydrazide (ADH) or N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) was used as a spacer to link the CP to carrier protein. All conjugates gave a high immune response with a boost after the second immunization. Conjugates prepared with ADH gave higher antibody… CONTINUE READING
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