Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumococcal vaccine on recurrent acute otitis media: a randomised study.

@article{Veenhoven2003EffectOC,
  title={Effect of conjugate pneumococcal vaccine followed by polysaccharide pneumococcal vaccine on recurrent acute otitis media: a randomised study.},
  author={Reinier H. Veenhoven and Debby Bogaert and Cuno S. P. M. Uiterwaal and Carole N. M. Brouwer and Herma H Kiezebrink and Jacob P. Bruin and E. P. F. Ijzerman and Peter Hermans and Ronald de Groot and Ben J. M. Zegers and Wietse Kuis and Ger T. Rijkers and Anne G M Schilder and Elisabeth A. M. Sanders},
  journal={Lancet},
  year={2003},
  volume={361 9376},
  pages={2189-95}
}
BACKGROUND Pneumococcal conjugate vaccine prevents recurrent acute otitis media (AOM) in infants immunised at 2, 4, 6, and 12-15 months of age. We aimed to find out whether this vaccine also prevents AOM in older children who have had previous episodes of AOM. METHODS In this double-blind, randomised study, we enrolled 383 patients aged 1-7 years who had had two or more episodes of AOM in the year before entry. Randomisation was stratified in four groups according to age (12-24 months vs 25… CONTINUE READING

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