Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria.

@article{Adjei2008EffectOC,
  title={Effect of concomitant artesunate administration and cytochrome P4502C8 polymorphisms on the pharmacokinetics of amodiaquine in Ghanaian children with uncomplicated malaria.},
  author={George Obeng Adjei and Kim Kristensen and Bamenla Quarm Goka and Lotte C G Hoegberg and Michael Alifrangis and Onike P. Rodrigues and Jorgen A. L. Kurtzhals},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 12},
  pages={4400-6}
}
Artesunate (AS) is used in combination with amodiaquine (AQ) as first-line treatment for uncomplicated malaria in many countries. We investigated the effect of concomitant AS administration on the pharmacokinetics of AQ and compared concentrations of desethylamodiaquine (DEAQ), the main metabolite of AQ, in plasma between patients with different variants of the cytochrome P4502C8 (CYP2C8) gene. A two-compartment model was fitted to 169 plasma DEAQ concentrations from 103 Ghanaian children aged… CONTINUE READING

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High prevalence of the cytochrome P450 2C8*2 mutation in Northern Ghana

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