Effect of concanavalin A on the functional activity of hemolytic antibody.

@article{Langone1977EffectOC,
  title={Effect of concanavalin A on the functional activity of hemolytic antibody.},
  author={John J. Langone and Michael D. P. Boyle and Tibor Borsos},
  journal={Immunological communications},
  year={1977},
  volume={6 3},
  pages={283-96}
}
Concanavalin A (Con A), either in solution or insolubilized by covalent binding to Sepharose 4B, can inhibit the ability of fluid phase 19S, but not 7S, anti-Forssman antibody to sensitize sheep red cells (E) toward lysis by excess guinea pig complement. The efficiency of 19S antibody is unaffected when E are treated with Con A before sensitization or when antibody sensitized cells (EA) are exposed to the lectin before complement is added. Although whole complement activity is retained on a… CONTINUE READING