Effect of compression speeds on the compaction properties of a 1:1 paracetamol-microcrystalline cellulose mixture prepared by single compression and by combinations of pre-compression and main-compression.

@article{Akande1997EffectOC,
  title={Effect of compression speeds on the compaction properties of a 1:1 paracetamol-microcrystalline cellulose mixture prepared by single compression and by combinations of pre-compression and main-compression.},
  author={Akande and Rubinstein and L Rowe and Ford},
  journal={International journal of pharmaceutics},
  year={1997},
  volume={157 2},
  pages={127-136}
}
A 1:1 blend of paracetamol and microcrystalline cellulose was compacted at different compression speeds by single compression or combinations of pre- and main-compression. The tensile strengths of the tablets decreased from 0.74+/-0.01 to 0.44+/-0.05 MPa as the compression speed was increased from 78 to 390 mm/s when a single compression pressure of 80 MPa was used to compress the tablets. When combinations of pre- and main-compression of 320 and 240 MPa were used to compress the tablets… CONTINUE READING

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