Effect of complex formation on drug absorption. 8. Intestinal transfer characteristics of the salicylamide-caffeine system.

  title={Effect of complex formation on drug absorption. 8. Intestinal transfer characteristics of the salicylamide-caffeine system.},
  author={R. H. Reuning and G. Levy},
  journal={Journal of pharmaceutical sciences},
  volume={57 8},
Abstract Salicylamide and caffeine form a complex in aqueous solution which has an apparent lipoid-aqueous partition coefficient intermediate between the partition coefficients of free salicylamide and free caffeine. The transfer rate of salicylamide across the cannulated everted intestine of the rat is decreased in the presence of caffeine at a concentration sufficient to complex an appreciable fraction of the salicylamide. on the other hand, complex formation with salicylamide has no… Expand

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