Effect of commonly used organic solvents on the kinetics of cytochrome P450 2B6- and 2C8-dependent activity in human liver microsomes.

@article{Vuppugalla2007EffectOC,
  title={Effect of commonly used organic solvents on the kinetics of cytochrome P450 2B6- and 2C8-dependent activity in human liver microsomes.},
  author={Ragini Vuppugalla and S. Y. Chang and Hongjian Zhang and Punit H. Marathe and David Rodrigues},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2007},
  volume={35 11},
  pages={1990-5}
}
The effect of common organic solvents on the activities of various human cytochromes P450 has been reported. However, very little is known about their influence on CYP2B6 and CYP2C8 enzymes. The purpose of this study was to investigate the effect of solvents on the kinetics of representative CYP2B6 (bupropion hydroxylase) and CYP2C8 (paclitaxel hydroxylase) reactions in human liver microsomes. Methanol, ethanol, dimethyl sulfoxide (DMSO), and acetonitrile were studied at increasing volumes (v/v… CONTINUE READING
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Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450

  • WF JrBusby, JM Ackermann, CL Crespi
  • Drug Metab Dispos 27:246–249
  • 1999

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