Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes.

@article{Chauret1998EffectOC,
  title={Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes.},
  author={Nathalie Chauret and Alain Gauthier and Deborah A. Nicoll-Griffith},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1998},
  volume={26 1},
  pages={1-4}
}
In this study, we report the effect of methanol, dimethyl sulfoxide (DMSO), and acetonitrile on the cytochrome P450 (P450)-mediated metabolism of several substrates in human liver microsomes: phenacetin O-deethylation for P4501A2, coumarin 7-hydroxylation for P4502A6, tolbutamide hydroxylation for P4502C8/2C9, S-mephenytoin 4'-hydroxylation for P4502C19, dextromethorphan O-demethylation for P4502D6, chlorzoxazone 6-hydroxylation for P4502E1, and testosterone 6beta-hydroxylation for P4503A4… CONTINUE READING
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