Effect of combining an ACE inhibitor and an angiotensin II receptor blocker on plasma and kidney tissue angiotensin II levels.

@article{Komine2002EffectOC,
  title={Effect of combining an ACE inhibitor and an angiotensin II receptor blocker on plasma and kidney tissue angiotensin II levels.},
  author={Norikuri Komine and Ser J Khang and Lucinda M Wead and Roland C. Blantz and Francis B Gabbai},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2002},
  volume={39 1},
  pages={159-64}
}
Increased angiotensin II (AII) activity has been recognized as a risk factor for progression of kidney disease. There is increasing clinical evidence that combining an angiotensin-converting enzyme (ACE) inhibitor with an AII receptor blocker (ARB) reduces proteinuria and blood pressure in patients with renal disease, although the mechanism of this synergistic effect remains poorly defined. This study tested whether the combination of an ACE inhibitor and an ARB reduces plasma AII (AIIp) and… CONTINUE READING