Effect of combined oxidative and nitrosative stress on Neisseria meningitidis.

@article{Dyet2006EffectOC,
  title={Effect of combined oxidative and nitrosative stress on Neisseria meningitidis.},
  author={Kristin H. Dyet and James W. B. Moir},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 1},
  pages={
          197-9
        }
}
  • K. Dyet, J. Moir
  • Published 1 February 2006
  • Medicine, Biology
  • Biochemical Society transactions
Reactive oxygen and nitrogen species are produced by the human immune system in response to infection. Methods to detoxify these reactive species are vital to the survival of human pathogens, such as Neisseria meningitidis, which is the major aetiological agent of bacterial meningitis. Following activation, macrophages produce superoxide (O(2)(-)), hydrogen peroxide (H(2)O(2)) and nitric oxide (NO). The toxicity of O(2)(-), generated using X/Xo (xanthine/xanthine oxidase), and H(2)O(2) was… 

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References

SHOWING 1-10 OF 17 REFERENCES
Nitric Oxide Detoxification Systems Enhance Survival of Neisseria meningitidis in Human Macrophages and in Nasopharyngeal Mucosa
TLDR
It is shown that norB, and to a lesser extent cycP, enhance survival of N. meningitidis within primary human macrophages, and that the meningococcus requires active NO detoxification systems for optimal survival during experimental nasopharyngeal colonization and processing by human phagocytic cells.
Defenses against oxidative stress in Neisseria gonorrhoeae and Neisseria meningitidis: distinctive systems for different lifestyles.
TLDR
It is shown that accumulation of Mn also confers resistance to hydrogen peroxide killing via a catalase-independent mechanism and differences in oxidative defenses in the pathogenic Neisseria are most likely a result of their localization in different ecological niches.
Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli
TLDR
Exposure to NO resulted in minimal toxicity, but greatly potentiated (up to 1,000-fold) H2O2-mediated killing, as evaluated by a clonogenic assay, and a possible mechanism of modulation of H1N1-mediated toxicity is suggested.
Nitric Oxide Metabolism in Neisseria meningitidis
TLDR
It is shown that N. meningitidis can support growth microaerobically by the denitrification of nitrite via NO and that norB is required for anaerobic growth with nitrite and NorB and, to a lesser extent, the cycP gene product cytochrome c' are able to counteract toxicity due to exogenously added NO.
Nitric oxide interferes with plant photo-oxidative stress by detoxifying reactive oxygen species
Oxidative stress within chloroplasts is originated due to light-dependent O 2 reduction. This may be exacerbated by bipyridinium herbicides, which act at photosystem I as artificial electron
A mechanism by which nitric oxide accelerates the rate of oxidative DNA damage in Escherichia coli
TLDR
The filamentation of the dead cells, and their protection by cell‐permeable iron chelators, indicated that NO/H2O2 killed cells by damaging their DNA through the Fenton reaction, and the possibility that H 2O2 and NO synergize when macrophages attack captive bacteria is discussed.
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection.
TLDR
It is demonstrated that NO possesses properties which protect against ROS toxicity and how the use of different NO donor compounds can lead to different conclusions about the role that NO can play in the cytotoxicity of ROS is demonstrated.
Bacterial [Cu,Zn]-Cofactored Superoxide Dismutase Protects Opsonized, Encapsulated Neisseria meningitidis from Phagocytosis by Human Monocytes/Macrophages
TLDR
The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.
Investigation of Oxidative Stress Defenses of Neisseria gonorrhoeae by Using a Human Polymorphonuclear Leukocyte Survival Assay
TLDR
It is shown that mutant strains of N. gonorrhoeae lacking oxidative stress defenses are identical to the wild type when tested in an ex vivo survival assay using human polymorphonuclear leukocytes.
Arch. Biochem. Biophys
  • Arch. Biochem. Biophys
  • 1996
...
...