Effect of combined oxidative and nitrosative stress on Neisseria meningitidis.

  title={Effect of combined oxidative and nitrosative stress on Neisseria meningitidis.},
  author={Kristin H. Dyet and James W. B. Moir},
  journal={Biochemical Society transactions},
  volume={34 Pt 1},
  • K. Dyet, J. Moir
  • Published 1 February 2006
  • Medicine, Biology
  • Biochemical Society transactions
Reactive oxygen and nitrogen species are produced by the human immune system in response to infection. Methods to detoxify these reactive species are vital to the survival of human pathogens, such as Neisseria meningitidis, which is the major aetiological agent of bacterial meningitis. Following activation, macrophages produce superoxide (O(2)(-)), hydrogen peroxide (H(2)O(2)) and nitric oxide (NO). The toxicity of O(2)(-), generated using X/Xo (xanthine/xanthine oxidase), and H(2)O(2) was… 

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