Effect of combined oxidative and nitrosative stress on Neisseria meningitidis.

@article{Dyet2006EffectOC,
  title={Effect of combined oxidative and nitrosative stress on Neisseria meningitidis.},
  author={Kristin Dyet and Jonathon Moir},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 1},
  pages={
          197-9
        }
}
Reactive oxygen and nitrogen species are produced by the human immune system in response to infection. Methods to detoxify these reactive species are vital to the survival of human pathogens, such as Neisseria meningitidis, which is the major aetiological agent of bacterial meningitis. Following activation, macrophages produce superoxide (O(2)(-)), hydrogen peroxide (H(2)O(2)) and nitric oxide (NO). The toxicity of O(2)(-), generated using X/Xo (xanthine/xanthine oxidase), and H(2)O(2) was… CONTINUE READING

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