Effect of combination therapy with thyroxine (T4) and 3,5,3'-triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study.

@article{Nygaard2009EffectOC,
  title={Effect of combination therapy with thyroxine (T4) and 3,5,3'-triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study.},
  author={Birte Nygaard and Ebbe Winther Jensen and Jan Kvetny and Anne Elisabeth Jarl\ov and Jens Faber},
  journal={European journal of endocrinology},
  year={2009},
  volume={161 6},
  pages={895-902}
}
BACKGROUND Treatment of hypothyroidism with 3,5,3'-triiodothyronine (T(3)) is controversial. A recent meta-analysis concludes that no evidence is present in favour of using T(3). However, the analysis included a mixture of different patient groups and dose-regimens. OBJECTIVE To compare the effect of combination therapy with thyroxine (T(4)) and T(3) versus T(4) monotherapy in patients with hypothyroidism on stable T(4) substitution. Study design Double-blind, randomised cross-over. Fifty… CONTINUE READING
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