Effect of combination therapy with dipyridamole and quinapril in diabetic nephropathy.

BACKGROUND/AIMS Dipyridamole stimulates nitric oxide action via inhibition of phosphodiesterase and also has an antioxidant effect. ACE inhibitor reduces glomerular pressure and enhances NO action via increased bradykinin. Thus, we evaluated the effect of the combination of dipyridamole and ACE inhibitor in diabetic nephropathy. METHODS Streptozotocin… CONTINUE READING