Effect of combination antiretroviral therapy on cerebrospinal fluid HIV RNA, HIV resistance, and clinical manifestations of encephalopathy.

@article{McCoig2002EffectOC,
  title={Effect of combination antiretroviral therapy on cerebrospinal fluid HIV RNA, HIV resistance, and clinical manifestations of encephalopathy.},
  author={Cynthia C McCoig and Mar{\'i}a Mercedes Castrej{\'o}n and Elizabeth Casta{\~n}o and Onix De Suman and Carmen B{\'a}ez and Wilfrido Redondo and Daniel R. McClernon and Susan A Danehower and Ernest Randall Lanier and Carol E. Richardson and Amy Beth Keller and Seth Hetherington and Xavier S{\'a}ez-Llorens and Octavio Ramilo},
  journal={The Journal of pediatrics},
  year={2002},
  volume={141 1},
  pages={36-44}
}
OBJECTIVES This study evaluated the effect of treatment with abacavir/lamivudine/zidovudine versus lamivudine/zidovudine on cerebrospinal fluid (CSF) human immunodeficiency virus (HIV) RNA and clinical manifestations of HIV encephalopathy in children. STUDY DESIGN HIV-infected children 7 months to 10 years of age (n = 23) were studied. CSF and plasma were obtained at baseline and weeks 8, 16, and 48. Genotype analysis of HIV was attempted at baseline and week 48. Neurologic evaluations were… CONTINUE READING