Effect of cold-storage in the accumulation of bioreactive substances in platelet concentrates treated with second messenger effects.


BACKGROUND AND OBJECTIVES The mandatory 5-day of shelf-life platelet concentrates (PCs) creates outdating and inventory control problems in blood banking. Moreover, storage of PCs at 22-24 degrees C has been associated with a time-dependent accumulation of pyrogenic cytokines, potentially harmful for recipients. Previous studies have shown that… (More)

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