Effect of colchicine and cytokines on MEFV expression and C5a inhibitor activity in human primary fibroblast cultures.

@article{Abedat2002EffectOC,
  title={Effect of colchicine and cytokines on MEFV expression and C5a inhibitor activity in human primary fibroblast cultures.},
  author={Suzan Abedat and Simcha Urieli-Shoval and Eli Shapira and Sima Calko and Eldad Ben-Ch{\'e}trit and Yaacov Matzner},
  journal={The Israel Medical Association journal : IMAJ},
  year={2002},
  volume={4 1},
  pages={7-12}
}
BACKGROUND Familial Mediterranean fever is an autosomal recessive disease characterized by sporadic attacks of inflammation affecting the serosal spaces. The gene associated with FMF (MEFV), mainly expressed in neutrophils, was recently found to be expressed also in primary cultures of serosal origin (peritoneal and synovial fibroblasts). A C5a inhibitor, previously detected in normal serosal fluids, was recently identified in serosal cultures as well, and was found to be deficient in serosal… CONTINUE READING