Effect of coenzyme Q10 on mitochondrial respiratory proteins in trigeminal neuralgia

@article{Khuankaew2018EffectOC,
  title={Effect of coenzyme Q10 on mitochondrial respiratory proteins in trigeminal neuralgia},
  author={Chutikorn Khuankaew and Nattayaporn Apaijai and Passakorn Sawaddiruk and Thidarat Jaiwongkam and Sasiwan Kerdphoo and Surawut Pongsiriwet and Wichittra Tassaneeyakul and Nipon Chattipakorn and Siriporn C. Chattipakorn},
  journal={Free Radical Research},
  year={2018},
  volume={52},
  pages={415 - 425}
}
Abstract Trigeminal neuralgia (TN) is the neuropathic pain. Mitochondrial dysfunction, increased oxidative stress, and inflammation demonstrated in chronic pain. Carbamazepine (CBZ) is the first-line drug for TN, however, it is still insufficient. Coenzyme Q10 (CoQ10) has been used as the additional supplement for pain therapy. Nonetheless, mitochondrial respiratory proteins, oxidative stress, and inflammation in TN, and the add-on effects of CoQ10 on those defects have never been investigated… 

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References

SHOWING 1-10 OF 30 REFERENCES

Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia?

Results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating at mitochondria as a possible new therapeutic target.

NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10.

Results show an important role for the NLRP3 inflammasome in the pathogenesis of FM, and the capacity of CoQ10 in the control of inflammaome is suggested to be a new therapeutic intervention for the disease.

Coenzyme Q10 Therapy

Oral administration of CoQ10 is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit and new formulations have been developed that increase CoQ 10 absorption and tissue distribution.

Clinical applications of coenzyme Q10.

Recent data indicate that CoQ10 affects expression of genes involved in human cell signalling, metabolism and transport and some of the effects of CoQ20 supplementation may be due to this property, which may provide a significant symptomatic benefit.

Coenzyme Q10 effects in neurodegenerative disease

CoQ10 is widely available in multiple formulations and is very well tolerated with minimal adverse effects, making it an attractive potential therapy, and Phase III trials of high-dose CoQ10 in large sample sizes are needed to further ascertain the effects of CoQ 10 in neurodegenerative diseases.

Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease

The role of oxidative stress and mitophagy in the pathophysiology of fibromyalgia may be supported, as mitochondrial dysfunction was associated with increased expression of autophagic genes and the elimination of dysfunctional mitochondria with Mitophagy.

The contribution of mitochondria to sensory processing and pain.

  • S. Flatters
  • Biology, Medicine
    Progress in molecular biology and translational science
  • 2015

Dysregulation of Cellular Calcium Homeostasis in Chemotherapy-Evoked Painful Peripheral Neuropathy

It is concluded that a similar abnormality of cellular Ca2+ homeostasis contributes to the pain caused by paclitaxel, vincristine, and ddC, but not posttraumatic painful peripheral neuropathy.

Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement

A role for mitochondrial dysfunction and oxidative stress in the headache symptoms associated with FM is suggested and CoQ10 supplementation should be examined in a larger placebo controlled trial as a possible treatment in FM.