Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype.

@article{Mikus1997EffectOC,
  title={Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype.},
  author={Gerd Mikus and B Trausch and Christoph Walter Rodewald and Ute Hofmann and Kai Richter and Th. Gramatt{\'e} and Michel F Eichelbaum},
  journal={Clinical pharmacology and therapeutics},
  year={1997},
  volume={61 4},
  pages={459-66}
}
BACKGROUND Codeine is widely used as an analgesic and antitussive drug. The analgesic effect of codeine is mediated by its metabolite morphine, which is formed by the polymorphically expressed enzyme CYP2D6; therefore poor metabolizers have no analgesia after administration of codeine. Like other opiates, codeine causes a delay of gastric emptying and… CONTINUE READING