Effect of cocultivation on sister chromatid exchange frequencies in Bloom's syndrome and normal fibroblast cells

Abstract

BLOOM'S syndrome (BS) is a rare, autosomal recessive human disorder, characterised by growth retardation, sunlight-induced facial skin eruptions, low immunological competence and a high incidence of cancer1–4. Lymphocytes, and to a lesser extent, fibroblasts, cultured from affected individuals exhibit unusually high levels of chromosomal aberrations2,5,6… (More)
DOI: 10.1038/273538a0

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