Effect of cocaine metabolites on behavior: Possible neuroendocrine mechanisms

@article{Gs1996EffectOC,
  title={Effect of cocaine metabolites on behavior: Possible neuroendocrine mechanisms},
  author={Schuelke Gs and Konkol Rj and Terry Lc and Madden Ja},
  journal={Brain Research Bulletin},
  year={1996},
  volume={39},
  pages={43-48}
}
  • Schuelke Gs, Konkol Rj, +1 author Madden Ja
  • Published 1996
  • Biology
  • Brain Research Bulletin
  • Abstract The predominant cocaine metabolites were tested for central nervous system effects by intracerebroventricular (ICV) administration in rats. We found two types of responses: cocaine, norcocaine (NC), benzoylecgonine (BE), and benzoylnorecgonine (Nor BE) produced stimulatory effects, whereas ecgonine methyl ester (EME) and ecgonine (EC) resulted in no specific effect or sedation. A novel metabolite interaction was revealed when rats were pretreated with EME, which inhibited both… CONTINUE READING
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